Description

2-Piperidinemethanamine, (2S)- is a chiral amine building block of significant importance in advanced organic synthesis. Its value lies in its stereochemically defined piperidine scaffold, which is a privileged structure in medicinal chemistry for modulating biological activity. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications in central nervous system (CNS) and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological receptors and enzymes.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the specific stereochemistry can influence efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Fine Chemical Synthesis: A versatile building block for constructing complex nitrogen-containing heterocycles in custom synthesis and process development.

Basic Information

Product Name	2-Piperidinemethanamine, (2S)-
CAS No.	111478-77-4
Molecular Formula	C6H14N2
Molecular Weight	114.19 g/mol
Synonyms	(S)-2-(Aminomethyl)piperidine; (2S)-2-Piperidinylmethanamine; (S)-2-Piperidinemethylamine; L-2-(Aminomethyl)piperidine; (S)-2-Piperidinemethanamine; (S)-Piperidine-2-methanamine; (2S)-2-(Aminomethyl)piperidine
EINECS	Contact for details

Quality Control

Our 2-Piperidinemethanamine, (2S)- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. We provide comprehensive analytical data including chiral purity to support regulatory filings. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.