Description

O(6)-(2-Hydroxyethyl)-2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically an adduct of deoxyguanosine. This compound is of significant value as a critical reference standard and biomarker in biochemical and toxicological research. It is primarily needed by research institutions and pharmaceutical companies engaged in studies of DNA damage, mutagenesis, and the metabolic pathways of alkylating agents.

Application

• Biomarker Research: Used as a quantitative standard for detecting and measuring DNA adducts formed by exposure to specific environmental or therapeutic alkylating agents.
• Toxicology Studies: Essential for investigating the mechanisms of genotoxicity and carcinogenicity associated with certain chemicals.
• Analytical Reference Standard: Serves as a high-purity calibrant in advanced analytical techniques such as LC-MS/MS and HPLC for method development and validation.
• DNA Repair Studies: Employed in enzymatic assays to study the activity and specificity of DNA repair enzymes like O6-alkylguanine-DNA alkyltransferase (AGT).
• Pharmaceutical Development: Used in the research and development of chemotherapeutic agents that target or involve alkyltransferase pathways.

Basic Information

Product Name	O(6)-(2-Hydroxyethyl)-2'-Deoxyguanosine
CAS No.	111447-35-9
Molecular Formula	C12H17N5O5
Molecular Weight	311.29 g/mol
Synonyms	O6-HEdG; O6-(2-Hydroxyethyl)-2'-deoxyguanosine; 2'-Deoxy-O6-(2-hydroxyethyl)guanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[(2-hydroxyethyl)amino]-1H-purin-2-one; O6-Hydroxyethyldeoxyguanosine; N6-(2-Hydroxyethyl)-2'-deoxyguanosine (common misnomer); DNA Adduct Standard
EINECS	Contact for details

Quality Control

Our O(6)-(2-Hydroxyethyl)-2'-Deoxyguanosine is produced under strict quality management protocols to ensure the high purity and consistency required for research applications. Each batch is characterized using advanced spectroscopic and chromatographic methods. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.