Description

Coenzyme Q10-D6 is a stable isotope-labeled analog of the vital endogenous cofactor, Ubiquinone, where six hydrogen atoms are replaced by deuterium. This labeling is crucial for providing an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is an indispensable tool for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and clinical diagnostics sectors who require precise quantification of CoQ10 levels in complex matrices.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a quantitative reference standard in bioanalytical methods for CoQ10 in plasma, serum, and tissue samples.
• Pharmacokinetic and Metabolic Studies: Enables accurate tracking of CoQ10 absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Nutraceutical and Pharmaceutical QC: Ensures precise assay and content uniformity testing of CoQ10 in finished products like softgel capsules and tablets.
• Diagnostic Assay Development: Used in developing high-sensitivity tests for CoQ10 deficiency syndromes and monitoring therapeutic efficacy.
• Stable Isotope Dilution Assays (SIDA): The gold-standard method for achieving maximum accuracy in quantifying CoQ10 in food, supplements, and biological fluids.
• Research on Mitochondrial Function: Facilitates precise measurement of CoQ10 in studies related to energy metabolism, oxidative stress, and aging.

Basic Information

Product Name	Coenzyme Q10-D6
CAS No.	110971-02-3
Molecular Formula	C59H84D6O4
Molecular Weight	869.36 g/mol
Synonyms	Ubiquinone-10-D6; CoQ10-D6; 2,3-Dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone-D6; Vitamin Q10-D6; 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione-D6; Isotopically Labeled Coenzyme Q10
EINECS	Contact for details

Quality Control

Our Coenzyme Q10-D6 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic purity, and identification. We adhere to relevant industry standards for reference materials to ensure reliability and traceability in your analyses.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.