Description

D-Alanine, n-D-Alanyl-, Labeled With Carbon-14 (9Ci) is a high-specific-activity, isotopically labeled derivative of the non-proteinogenic amino acid D-alanine. This compound is an essential tool for advanced metabolic and pharmacokinetic studies, enabling precise tracking and quantification in biological systems. It is primarily utilized by research scientists and process developers in the pharmaceutical, biotechnology, and agrochemical industries for tracer studies, drug metabolism research (DMPK), and biochemical pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities, particularly those incorporating D-amino acid motifs.
• Biochemical Pathway Analysis: Enables the elucidation of specific metabolic pathways in microorganisms or cell cultures that utilize D-alanine, such as bacterial cell wall (peptidoglycan) biosynthesis.
• Mechanistic Research: Serves as a critical probe for studying enzyme mechanisms, substrate specificity of racemases, and transport proteins involved in D-amino acid handling.
• Agrochemical Research: Applied in environmental fate studies and mode-of-action research for herbicides or fungicides that target pathways involving alanine metabolism.
• Quality Control & Reference Standard: Can be employed as an internal standard in advanced analytical methods like LC-MS for the quantification of related compounds in complex matrices.

Basic Information

Item	Details
Product Name	D-Alanine, n-D-Alanyl-, Labeled With Carbon-14 (9Ci)
CAS No.	110652-05-6
Molecular Formula	C6H1214CN2O3 *
Molecular Weight	~163.17 g/mol (unlabeled) **
Synonyms	Carbon-14 Labeled D-Alanyl-D-alanine; [14C]-D-Ala-D-Ala; D-Alanyl-D-alanine-14C; D-Ala-D-Ala-14C; Radiolabeled D-Alanylalanine; (2R)-2-[[(2R)-2-Aminopropanoyl]amino]propanoic acid (Carbon-14 Labeled); DADALA-14C; D-Alanine, N-[(1R)-1-carboxyethyl]- (Carbon-14 Labeled)
EINECS	Contact for details

* Formula indicates position of Carbon-14 label. ** Exact molecular weight depends on the specific activity and labeling position.

Quality Control

Every batch of our Carbon-14 labeled D-Alanyl-D-alanine is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Production adheres to cGMP guidelines where applicable for non-clinical research materials. Comprehensive analysis includes determination of radiochemical purity (by HPLC with radiometric detection), specific activity, and chemical identity. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dry, inert atmosphere. Follow all applicable laboratory safety and radiation safety protocols for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Specific Activity	~9 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent (for solution formats)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.