Description

2'-Fluoro-2',3'-Dideoxyadenosine is a fluorinated nucleoside analog of significant interest in pharmaceutical research and development. This modified nucleoside serves as a critical building block in the synthesis of novel antiviral and anticancer agents, particularly as a key intermediate for prodrugs and nucleotide analogs. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who are developing next-generation therapeutics targeting viral replication and cellular proliferation.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of antiviral nucleotide analogs, including potential treatments for hepatitis and other viral infections.
• Anticancer Drug Research: Used as a building block for developing nucleoside-based chemotherapeutic agents that target DNA synthesis in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate polymerase mechanisms and inhibition.
• Prodrug Development: Serves as a core structure for designing prodrugs with enhanced bioavailability and targeted delivery.
• Antisense Oligonucleotide Synthesis: Can be incorporated into oligonucleotides to modulate their stability and binding affinity for therapeutic applications.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2'-Fluoro-2',3'-Dideoxyadenosine
CAS No.	110143-05-0
Molecular Formula	C10H12FN5O2
Molecular Weight	253.23 g/mol
Synonyms	2'-F-ddA; 9-[(2R,5S)-5-Fluoro-2,5-dihydro-2-furanyl]-9H-purin-6-amine; 2'-Fluoro-2',3'-dideoxyadenosine; 2'-F-2',3'-ddA; 2'-Fluoro-ddA; 2'-F-dideoxyadenosine; 2'-Fluoro-2'-deoxyadenosine (related); Adenosine, 2'-fluoro-2',3'-dideoxy-
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-2',3'-Dideoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed in a dry environment. For long-term storage, consider under inert atmosphere to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.