Description

1,N(2)-Ethenodeoxyguanosine is a modified nucleoside adduct of significant interest in biochemical and toxicological research. This compound serves as a critical biomarker for DNA damage resulting from exposure to specific environmental carcinogens and endogenous metabolic processes. It is essential for researchers and scientists in the fields of molecular toxicology, cancer research, and analytical chemistry who require high-purity reference standards for accurate detection and quantification of DNA lesions.

Application

• Biomarker Research: Used as a reference standard for detecting and quantifying etheno-DNA adducts in biological samples, linking exposure to oxidative stress or vinyl monomers with genetic damage.
• Toxicology Studies: Essential for investigating the mechanisms of carcinogenesis induced by environmental toxins like vinyl chloride and urethane.
• Analytical Method Development: Serves as a critical calibrant and internal standard in advanced analytical techniques such as LC-MS/MS, GC-MS, and 32P-postlabeling assays.
• DNA Repair Studies: Employed to study the efficiency and pathways of DNA repair enzymes specific to exocyclic adducts.
• Oxidative Stress Assessment: A key analyte in studies measuring the impact of lipid peroxidation and inflammation on DNA integrity.
• Pharmaceutical Safety Evaluation: Used in preclinical studies to assess the genotoxic potential of new drug candidates.

Basic Information

Product Name	1,N(2)-Ethenodeoxyguanosine
CAS No.	108929-11-9
Molecular Formula	C12H15N5O4
Molecular Weight	293.28 g/mol
Synonyms	1,N2-Etheno-2'-deoxyguanosine; 1,N2-ε-dG; ε-dG; Etheno-dG; 1,N2-Etheno-2'-deoxyguanosine; 3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydro-6,8-dioxoimidazo[1,2-a]purine; 1,N2-(1,2-Etheno)-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Our 1,N(2)-Ethenodeoxyguanosine is manufactured under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and stability. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analyses. Our quality system is designed to meet the rigorous demands of analytical and biochemical research, ensuring reliable and reproducible results for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.