Description

(R)-4-Amino-3-(Naphthalen-1-Yl)Butanoic Acid CAS NO 108827-19-6 is a chiral, non-proteinogenic amino acid derivative featuring a naphthyl group, making it a valuable building block in asymmetric synthesis. This compound is essential for the research and development of novel pharmaceuticals, particularly as a precursor for active pharmaceutical ingredients (APIs) and chiral ligands. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on medicinal chemistry and catalysis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Chiral Ligand/ Catalyst Precursor: Used in the development of asymmetric catalysts for enantioselective transformations in fine chemical production.
• Peptidomimetic Research: Serves as a constrained amino acid analog for designing and synthesizing peptide-like molecules with enhanced metabolic stability.
• Chemical Biology Probe: Employed in the study of enzyme mechanisms and receptor-ligand interactions due to its unique steric and electronic properties.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(R)-4-Amino-3-(Naphthalen-1-Yl)Butanoic Acid
CAS No.	108827-19-6
Molecular Formula	C₁₄H₁₅NO₂
Molecular Weight	229.28 g/mol
Synonyms	(R)-4-Amino-3-(1-naphthyl)butyric acid; (R)-3-(Naphthalen-1-yl)-4-aminobutanoic acid; (R)-γ-Amino-β-(1-naphthyl)butyric acid; (R)-Homo-β-(1-naphthyl)-γ-aminobutyric acid; (R)-4-Amino-3-(1-naphthalenyl)butanoic acid; (R)-AABA(1-Nap); (R)-1-Naphthyl-GABA derivative
EINECS	Contact for details

Quality Control

Our (R)-4-Amino-3-(Naphthalen-1-Yl)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.