Description

Dl-Glutamic-2-13C Acid is a stable isotope-labeled analog of glutamic acid, where the carbon atom at the 2-position is enriched with the 13C isotope. This compound is an essential tool for advanced research and analytical applications, providing a non-radioactive tracer for metabolic pathway studies and quantitative analysis. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, clinical diagnostics, and nutritional science who require precise isotopic labeling for mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Metabolic Research & Tracer Studies: Used as a stable isotope tracer to investigate glutamic acid metabolism, amino acid turnover, and related biochemical pathways in vivo and in vitro.
• Quantitative Mass Spectrometry (MS): Serves as an internal standard for the accurate quantification of endogenous glutamic acid levels in complex biological matrices like plasma, urine, and tissue samples.
• NMR Spectroscopy: Employed in structural and dynamic studies where 13C labeling provides enhanced sensitivity and resolution for analyzing molecular interactions and conformations.
• Pharmaceutical Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules containing glutamic acid moieties.
• Clinical Diagnostics: Applied in the development of advanced assays for metabolic disorders related to glutamate metabolism.
• Nutritional Science Research: Utilized to study protein digestion, amino acid absorption, and overall nitrogen metabolism in nutritional studies.

Basic Information

Product Name	Dl-Glutamic-2-13C Acid
CAS No.	108395-12-6
Molecular Formula	C413CH9NO4
Molecular Weight	148.11 g/mol (for 13C labeled form)
Synonyms	(±)-2-Aminopentanedioic-2-13C Acid; DL-Glutamic-2-13C Acid; Glutamic Acid-2-13C (racemic); 2-13C-DL-Glutamic Acid; 13C Labeled Glutamic Acid; 108395-12-6; DL-Glu-2-13C; (±)-Glutamic-2-13C Acid; 2-Aminoglutaric-2-13C Acid
EINECS	Contact for details

Quality Control

Our Dl-Glutamic-2-13C Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and isotopic enrichment, typically exceeding 99% chemical purity and 99 atom % 13C. Certificates of Analysis (COA) are provided, detailing results for identity (IR, NMR), assay (HPLC), isotopic enrichment (MS), and specific tests for related substances and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 99.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C
Chemical Purity (Titration)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.