Description

D-Fructose-1-13C CAS NO 108311-21-3 is a stable isotope-labeled analog of fructose, where the carbon-1 position is enriched with the 13C isotope. This compound is an essential tool for advanced metabolic research and analytical method development, providing a critical tracer for precise quantification and pathway elucidation. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in isotope dilution mass spectrometry (IDMS), nuclear magnetic resonance (NMR) spectroscopy, and clinical diagnostics.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as an internal standard for the accurate quantification of fructose and related metabolites in complex biological matrices like blood, urine, and tissue samples.
• Metabolic Flux Analysis (MFA): Used as a 13C tracer to map and quantify carbon flow through metabolic pathways such as glycolysis and the pentose phosphate pathway in cell cultures and in vivo studies.
• NMR Spectroscopy Studies: Provides a distinct spectroscopic signature for investigating carbohydrate metabolism, enzyme mechanisms, and structural dynamics at the molecular level.
• Clinical Diagnostic Assays: Employed in the calibration and development of high-precision diagnostic kits for conditions like diabetes and hereditary fructose intolerance.
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetics (DMPK) studies to trace the metabolic fate of new drug candidates.
• Nutritional Science Research: Enables detailed studies on fructose absorption, utilization, and its role in dietary metabolism.

Basic Information

Product Name	D-Fructose-1-13C
CAS No.	108311-21-3
Molecular Formula	C6H12O6 (with 13C at position 1)
Molecular Weight	181.15 g/mol (for 13C labeled form)
Synonyms	Fructose-1-13C; (3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one-1-13C; Levulose-1-13C; D-(-)-Fructose-1-13C; Fruit sugar-1-13C; 13C Labeled Fructose; [1-13C]-D-Fructose
EINECS	Contact for details

Quality Control

Our D-Fructose-1-13C is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for research applications. Each batch is characterized by advanced analytical techniques including NMR and LC-MS to confirm isotopic enrichment and chemical identity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (atom % 13C), chemical purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term stability, consider storage under inert atmosphere or in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (Atom % 13C)	≥ 99.0% at C-1
Specific Optical Rotation	-91° to -95° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.