Description

trans-Cevimeline Hydrochloride is a high-purity, non-racemic enantiomer of the muscarinic acetylcholine receptor agonist, Cevimeline. This compound is valued for its specific pharmacological activity and serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in advanced research and development. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing novel therapeutics for conditions like Sjögren's syndrome and other exocrine gland disorders.

Application

• Primary use as a pharmaceutical reference standard for analytical method development and validation.
• Key starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) targeting muscarinic receptors.
• Critical raw material in preclinical and clinical research for autonomic nervous system studies.
• Used in formulation development for controlled-release or specialty dosage forms.
• Essential component in quality control laboratories for impurity profiling and identity confirmation.
• Applied in academic and institutional research investigating cholinergic signaling pathways.

Basic Information

Item	Detail
Product Name	trans-Cevimeline Hydrochloride
CAS No.	107220-29-1
Molecular Formula	C10H17NOS • HCl
Molecular Weight	219.78 g/mol
Synonyms	(2R,3R)-2-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one hydrochloride; (2R,3R)-Cevimeline Hydrochloride; FTA Hydrochloride; trans-2-Methylspiro(1-azabicyclo[2.2.2]octane-3,5'-oxazolidin)-2'-one hydrochloride; UNII-6H7X6K55BP; AF102B hydrochloride; SNI-2011 hydrochloride
EINECS	Contact for details

Quality Control

Our trans-Cevimeline Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) with detailed chromatographic data (HPLC/GC) for identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting regulatory submissions for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.