Description

(2S,3R,4R,5R)-2-(6-Aminopurin-9-Yl)-5-[(Hydroxy-Methoxy-Phosphinothioyl)Oxymethyl]Oxolane-3,4-Diol is a high-purity nucleoside phosphorothioate analog, a critical building block in advanced pharmaceutical research and development. Its primary value lies in its role as a key intermediate for the synthesis of modified oligonucleotides, which are essential for therapeutic applications such as antisense and RNAi technologies. This compound is indispensable for research institutions, biotechnology firms, and pharmaceutical companies focused on developing next-generation genetic medicines and molecular diagnostics.

Application

• Oligonucleotide Synthesis: A vital phosphorothioate monomer for the solid-phase synthesis of therapeutic antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs).
• Pharmaceutical Intermediates: Serves as a key raw material in the production of active pharmaceutical ingredients (APIs) for genetic and antiviral therapies.
• Biochemical Research: Used in academic and industrial laboratories to study nucleic acid chemistry, enzyme mechanisms, and gene function.
• Diagnostic Probe Development: Employed in the creation of nuclease-resistant probes for molecular diagnostics and in-situ hybridization assays.
• Prodrug Development: Utilized in the design and synthesis of nucleotide prodrugs with enhanced cellular uptake and metabolic stability.

Basic Information

Product Name	(2S,3R,4R,5R)-2-(6-Aminopurin-9-Yl)-5-[(Hydroxy-Methoxy-Phosphinothioyl)Oxymethyl]Oxolane-3,4-Diol
CAS No.	107133-74-4
Molecular Formula	C11H16N5O6PS
Molecular Weight	377.31 g/mol
Synonyms	Adenosine 5'-(Thiomonophosphate); 5'-Thioadenylic Acid; 9-β-D-Arabinofuranosyladenine 5'-(Thiomonophosphate); 5'-O-Phosphorothioyladenosine; Adenosine 5'-O-Thiomonophosphate; Ara-A 5'-Thiomonophosphate; Nucleoside Phosphorothioate Monomer; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our (2S,3R,4R,5R)-2-(6-Aminopurin-9-Yl)-5-[(Hydroxy-Methoxy-Phosphinothioyl)Oxymethyl]Oxolane-3,4-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent decomposition. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.