Description

Adefovir CAS NO 106941-25-7 is a potent nucleotide analog reverse transcriptase inhibitor (NtRTI) used as an active pharmaceutical ingredient (API). This compound is critical for its antiviral activity, specifically targeting hepatitis B virus (HBV) replication. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of antiviral therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of antiviral medications for the treatment of chronic hepatitis B.
• Research & Development: Serves as a key reference standard and building block in virology research and the development of new nucleotide analog therapies.
• Preclinical Studies: Utilized in pharmacological and toxicological studies to evaluate efficacy, dosage, and safety profiles.
• Generic Drug Manufacturing: Essential for companies producing generic versions of adefovir dipivoxil-based drugs.
• Biochemical Research: Used in studies investigating viral polymerase mechanisms and resistance patterns.

Basic Information

Product Name	Adefovir
CAS No.	106941-25-7
Molecular Formula	C8H12N5O4P
Molecular Weight	273.19 g/mol
Synonyms	PMEA; 9-[2-(Phosphonomethoxy)ethyl]adenine; GS-0393; Adefovir Anhydrous; (2-(6-Amino-9H-purin-9-yl)ethoxy)methylphosphonic acid; Hepsera API (related to dipivoxil prodrug); Bis(POM)PMEA (precursor); CI-1012
EINECS	Contact for details

Quality Control

Our Adefovir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided and can be tailored to meet specific pharmacopeial (e.g., USP, EP) or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.