Description

cis-Paroxetine Hydrochloride is a high-purity, stereochemically defined active pharmaceutical ingredient (API) and key intermediate. This compound is critical for research and development in neuropharmacology, particularly in the study of selective serotonin reuptake inhibitors (SSRIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents and reference standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial chiral building block in the synthetic pathways for novel psychotropic drugs and SSRIs.
• Biochemical Research: Employed in in-vitro studies to investigate serotonin transporter (SERT) binding affinity, selectivity, and metabolic pathways.
• Process Chemistry & Development: Used for scaling up synthetic routes, optimizing yields, and studying stereoselective reactions in process R&D.
• Impurity Profiling: Acts as a specified isomer for identification and quantification of related substances in paroxetine hydrochloride drug substances and products.

Basic Information

Product Name	cis-Paroxetine Hydrochloride
CAS No.	105813-04-5
Molecular Formula	C19H21FNO3·HCl
Molecular Weight	365.84 g/mol
Synonyms	(3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride; (-)-trans-4-((p-Fluorophenyl)-3-[(3,4-methylenedioxy)phenoxy]methyl)piperidine hydrochloride; Paroxetine cis-isomer hydrochloride; Paroxetine Impurity C (Hydrochloride); (3S,4R)-Paroxetine hydrochloride
EINECS	Contact for details

Quality Control

Our cis-Paroxetine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (cis-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.