Description

8(R)-Hydroxy-(5Z,9E,11Z,14Z)-Eicosatetraenoic Acid CAS NO 105500-09-2 is a specialized hydroxy fatty acid and a bioactive metabolite of arachidonic acid. This compound is of significant interest for its role as a key intermediate in the biosynthesis of potent lipid mediators and for its utility in biochemical research. It is primarily sought after by researchers and developers in the pharmaceutical and life science sectors for use in metabolic pathway studies, inflammation research, and as a reference standard.

Application

• Biochemical Research: Used as a critical intermediate and reference standard for studying eicosanoid biosynthesis and metabolism.
• Pharmaceutical Development: Serves as a precursor or analytical standard in the research and development of novel anti-inflammatory agents and lipid-based therapeutics.
• Cell Signaling Studies: Employed in laboratory investigations to elucidate the role of hydroxy-eicosatetraenoic acids (HETEs) in cellular signaling pathways.
• Enzymology: Acts as a substrate or product in enzymatic assays for lipoxygenase and cytochrome P450 activity studies.
• Metabolomics: Utilized as a high-purity standard for the accurate identification and quantification of lipid metabolites in complex biological samples.

Basic Information

Product Name	8(R)-Hydroxy-(5Z,9E,11Z,14Z)-Eicosatetraenoic Acid
CAS No.	105500-09-2
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	8(R)-HETE; 8(R)-Hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic Acid; 8R-HETE; (8R)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic Acid; 8(R)-Hydroxyeicosatetraenoic Acid; 8R-Hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic Acid; AA metabolite 8(R)-HETE
EINECS	Contact for details

Quality Control

Our 8(R)-HETE is produced under stringent quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral analysis to confirm the R-configuration. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98% 8(R)-isomer
Solubility	Soluble in ethanol, DMSO, and dimethyl formamide

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.