Description

(S)-3-Methylmandelonitrile is a high-value chiral nitrile intermediate of significant importance in asymmetric synthesis. Its primary value lies in its role as a key building block for the production of enantiomerically pure pharmaceuticals and agrochemicals. This compound is essential for research and manufacturing chemists in the fine chemical, pharmaceutical, and agrochemical industries who require high-purity chiral precursors.

Application

• Pharmaceutical Intermediate: Critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and insecticides, where the specific stereochemistry is crucial for bioactivity.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective reactions.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research within university and corporate laboratories.

Basic Information

Product Name	(S)-3-Methylmandelonitrile
CAS No.	105367-21-3
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	(S)-2-Hydroxy-2-(3-methylphenyl)acetonitrile; (S)-α-Hydroxy-m-toluonitrile; (S)-3-Methylbenzaldehyde cyanohydrin; (S)-m-Methylmandelonitrile; (S)-2-(3-Methylphenyl)-2-hydroxyacetonitrile; (S)-3-Methylphenylglycolonitrile; (S)-Cyanohydrin of 3-methylbenzaldehyde
EINECS	Contact for details

Quality Control

Our (S)-3-Methylmandelonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing purity, enantiomeric excess (ee), and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.