Description

3-(3,5-Difluoro-4-Methoxyphenyl)Propionic Acid is a high-purity fluorinated aromatic propionic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoro-methoxy substitution pattern, which is essential for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting inflammation, metabolic disorders, and central nervous system (CNS) diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for high-performance display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Chemical Research: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to construct complex biaryl systems in academic and industrial R&D settings.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the effects of specific fluorine substitution patterns on aromatic system reactivity and molecular conformation.

Basic Information

Product Name	3-(3,5-Difluoro-4-Methoxyphenyl)Propionic Acid
CAS No.	105219-44-1
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	3-(3,5-Difluoro-4-methoxyphenyl)propanoic acid; 4-Methoxy-3,5-difluorohydrocinnamic acid; 3,5-Difluoro-4-methoxybenzenepropanoic acid; 3-(4-Methoxy-3,5-difluorophenyl)propionic acid; (3,5-Difluoro-4-methoxyphenyl)propanoic acid; Benzenepropanoic acid, 3,5-difluoro-4-methoxy-; 105219-44-1; Difluoromethoxyphenylpropionic Acid
EINECS	Contact for details

Quality Control

Our production of 3-(3,5-Difluoro-4-Methoxyphenyl)Propionic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.