Description

(R,R)-Reboxetine CAS NO 105017-38-7 is a specific enantiomer of the selective norepinephrine reuptake inhibitor (NRI) Reboxetine. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers and advanced research institutions focused on developing and producing novel antidepressant and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of enantiomerically pure (R,R)-Reboxetine mesylate, the active ingredient in certain antidepressant medications.
• Research & Development: Used in preclinical and clinical studies to investigate the specific pharmacological profile and efficacy of the (R,R)-enantiomer.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development, validation, and quality control in API manufacturing.
• Process Chemistry: Employed in the development and optimization of asymmetric synthesis routes and chiral separation processes.
• Academic Research: Utilized in university and institutional labs for studies in neuropharmacology, medicinal chemistry, and chirality.

Basic Information

Product Name	(R,R)-Reboxetine
CAS No.	105017-38-7
Molecular Formula	C19H23NO3
Molecular Weight	313.39 g/mol
Synonyms	(2R,αR)-2-[(2-Ethoxyphenoxy)phenylmethyl]morpholine; (R,R)-Reboxetine free base; (R,R)-FCE 20124; (R,R)-Vestra; (2R,αR)-Reboxetine; (R,R)-Reboxetine base; SSR 507; UNII-3JY80P5C5L
EINECS	Contact for details

Quality Control

Our (R,R)-Reboxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.