Description

4-(3,3,3-Trifluoropropyl)Benzoic Acid is a specialized fluorinated aromatic carboxylic acid building block, valued for its unique combination of a benzoic acid core and a trifluoropropyl side chain. This structure imparts significant lipophilicity and metabolic stability, making it a critical intermediate in advanced organic synthesis. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas targeting CNS disorders and inflammation, where the trifluoropropyl group enhances bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine atoms contribute to improved weatherfastness and biological activity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens in the production of high-performance liquid crystal displays (LCDs) due to its influence on molecular polarity and alignment.
• Polymer Modification: Incorporated as a monomer or additive to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties of specialty plastics and coatings.
• Organic Electronics: Utilized in the synthesis of charge-transport materials or semiconductors for OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile scaffold in medicinal and synthetic chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	4-(3,3,3-Trifluoropropyl)Benzoic Acid
CAS No.	104958-55-6
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	Benzoic acid, 4-(3,3,3-trifluoropropyl)-; 4-(3,3,3-Trifluoropropyl)benzoic acid; p-(3,3,3-Trifluoropropyl)benzoic acid; 4-(Trifluoropropyl)benzoic acid; 104958-55-6; 3,3,3-Trifluoropropyl-4-benzoic acid; 4-(Perfluoropropyl)benzoic acid (common misnomer); TFBA derivative
EINECS	Contact for details

Quality Control

Every batch of 4-(3,3,3-Trifluoropropyl)Benzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.