Description

1-[[4-(Trifluoromethyl)Phenyl]Methyl]Cinchonidinium Chloride (Wxc02412) is a high-purity, organocatalytic salt derived from cinchonidine, a natural chiral alkaloid. This compound matters as a highly effective and selective phase-transfer catalyst, enabling asymmetric synthesis with excellent enantioselectivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions. It is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries who require reliable, high-performance catalysts for producing enantiomerically pure intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Phase-Transfer Catalysis (PTC): Key catalyst for enantioselective alkylations, Michael additions, and Mannich reactions under mild conditions.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral drug candidates and APIs, including those for cardiovascular and central nervous system (CNS) therapies.
• Fine Chemical and Specialty Chemical Manufacturing: Used in the scalable synthesis of complex, optically active molecules for agrochemicals and advanced materials.
• Academic and Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Employed to develop more efficient, sustainable, and cost-effective manufacturing routes for chiral compounds.

Basic Information

Product Name	1-[[4-(Trifluoromethyl)Phenyl]Methyl]Cinchonidinium Chloride (Wxc02412)
CAS No.	104761-88-8
Molecular Formula	C₂₈H₂₉ClF₃N₂O
Molecular Weight	501.99 g/mol
Synonyms	N-[(4-(Trifluoromethyl)benzyl]cinchonidinium Chloride; Cinchonidine, 1-[(4-(trifluoromethyl)phenyl)methyl]-, chloride (1:1); (8α,9R)-1-[(4-(Trifluoromethyl)phenyl)methyl]cinchonidinium Chloride; Cinchonidinium, 1-[[4-(trifluoromethyl)phenyl]methyl]-, chloride; N-(4-Trifluoromethylbenzyl)cinchonidinium Chloride; PTC Catalyst from Cinchonidine; Cinchona-Based Phase Transfer Catalyst; Asymmetric Quaternary Ammonium Salt Catalyst
EINECS	Contact for details

Quality Control

Our 1-[[4-(Trifluoromethyl)Phenyl]Methyl]Cinchonidinium Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and tests for residual solvents and moisture to ensure it meets the high standards required for catalytic applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specification results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption, which can affect catalytic performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.