Description

3-(1-Oxo-2-Phenylethyl)-4(S)-(Phenylmethyl)-2-Oxazolidinone is a high-purity chiral oxazolidinone derivative, widely recognized as a versatile Evans auxiliary in asymmetric synthesis. Its primary value lies in enabling highly stereoselective aldol and alkylation reactions, which are critical for constructing complex molecular architectures with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), natural products, and other high-value chiral intermediates.

Application

• As a chiral auxiliary in Evans aldol reactions for the stereocontrolled formation of β-hydroxy carbonyl compounds.
• Facilitates asymmetric alkylation processes to install chiral centers with high enantiomeric excess.
• Key building block in the research-scale synthesis of pharmaceutical intermediates and complex natural products.
• Used in methodological development for academic and industrial organic chemistry research.
• Employed in the production of specialty fine chemicals requiring defined stereochemistry.
• Potential use in crafting chiral ligands or catalysts for asymmetric catalysis.

Basic Information

Product Name	3-(1-Oxo-2-Phenylethyl)-4(S)-(Phenylmethyl)-2-Oxazolidinone
CAS No.	104266-89-9
Molecular Formula	C18H17NO3
Molecular Weight	295.33 g/mol
Synonyms	(4S)-4-Benzyl-3-(2-oxo-2-phenylethyl)-1,3-oxazolidin-2-one; (S)-4-Benzyl-3-(2-oxo-2-phenylethyl)oxazolidin-2-one; Evans Auxiliary (Benzyl); N-[(Benzyloxy)carbonyl]-L-phenylalanine Oxazolidinone Derivative; (S)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone Related Auxiliary; Chiral Oxazolidinone Auxiliary; N-Acetyl-4(S)-Benzyl-3-(2-oxo-2-phenylethyl)-2-oxazolidinone
EINECS	Contact for details

Quality Control

Our 3-(1-Oxo-2-Phenylethyl)-4(S)-(Phenylmethyl)-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.