Description

1,25-Dihydroxy-24,24-Dimethyl-22-Dehydrovitamin D3 is a synthetic analog of the active form of Vitamin D, specifically engineered to modulate calcium and phosphate metabolism. This compound is of significant interest for its potent biological activity and enhanced metabolic stability compared to its natural counterpart. It is primarily utilized by pharmaceutical researchers and manufacturers in the development of novel therapeutics targeting bone disorders, psoriasis, and certain cancers, as well as in advanced biochemical studies of vitamin D receptor (VDR) signaling pathways.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation Vitamin D receptor agonists and antagonists for drug development.
• Research & Development: Used as a high-purity reference standard and active probe in biochemical and pharmacological research to study VDR-mediated gene expression and cell differentiation.
• Metabolic Studies: Employed in preclinical studies to investigate the treatment of conditions like osteoporosis, secondary hyperparathyroidism, and renal osteodystrophy.
• Dermatological Research: Investigated for potential applications in developing topical treatments for psoriasis due to its effects on keratinocyte proliferation.
• Oncology Research: Studied for its potential anti-proliferative and pro-differentiation effects on certain cancer cell lines in experimental settings.

Basic Information

Product Name	1,25-Dihydroxy-24,24-Dimethyl-22-Dehydrovitamin D3
CAS No.	104211-73-6
Molecular Formula	C₂₉H₄₄O₃
Molecular Weight	440.66 g/mol
Synonyms	1,25-Dihydroxy-24,24-dimethyl-22-dehydrocholecalciferol; 24,24-Dimethyl-1,25-dihydroxy-22-dehydrovitamin D3; 1α,25-Dihydroxy-24,24-dimethyl-22-dehydrovitamin D3; 24,24-Dimethyl-1α,25-dihydroxy-22-dehydrovitamin D3; 22-Dehydro-24,24-dimethyl-1,25-dihydroxyvitamin D3; EB 1089 (common research code name); Seocalcitol (pharmaceutical designation); Leo 210116
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-24,24-Dimethyl-22-Dehydrovitamin D3 is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide a Certificate of Analysis (COA) with each shipment, detailing batch-specific results for key parameters such as assay, purity, and related substances. Specifications can be aligned with customer requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.