Description

Leukotriene D4 Methyl Ester is a chemically modified derivative of the potent inflammatory mediator leukotriene D4 (LTD4). This compound is of significant value as a critical reference standard and research tool in the study of leukotriene pathways and receptor interactions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in respiratory and inflammatory disease research.

Application

• Biochemical Research: Used as a stable analog of LTD4 for studying the cysteinyl leukotriene (CysLT) receptors (CysLT1 and CysLT2) in signal transduction pathways.
• Drug Discovery & Development: Serves as a key pharmacological reference standard for screening and validating potential leukotriene receptor antagonists for asthma, allergic rhinitis, and other inflammatory conditions.
• Analytical Standard: Essential for method development and calibration in analytical techniques like HPLC and LC-MS for quantifying leukotrienes in biological samples.
• Enzyme Inhibition Studies: Employed in assays to investigate the activity of enzymes involved in the leukotriene synthesis cascade, such as leukotriene C4 synthase.
• Cell Biology & Immunology: Used to induce and model inflammatory responses in cell cultures to study mechanisms of inflammation and immune cell activation.

Basic Information

Product Name	Leukotriene D4 Methyl Ester
CAS No.	103476-23-9
Molecular Formula	C26H41NO6S
Molecular Weight	495.68 g/mol
Synonyms	LTD4 Methyl Ester; 5(S)-Hydroxy-6(R)-(S-cysteinylglycinyl)-7,9-trans-11,14-cis-eicosatetraenoic Acid Methyl Ester; Methyl (5S,6R)-6-[(2S)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]-7,9,11,14-eicosatetraenoate; (5S,6R)-LTD4 Methyl Ester; N-[4-[[(1S)-1-[[(1S,2S)-2-Heptyl-3-[(1E,3E,5Z,8Z)-1,3,5,8-tetraecatetraenyl]cyclopropyl]methyl]-2-hydroxyethyl]thio]-1-carboxybutyl]glycine Methyl Ester
EINECS	Contact for details

Quality Control

Our Leukotriene D4 Methyl Ester is produced and handled under strict quality protocols to ensure batch-to-batch consistency and integrity for sensitive research applications. All materials are subjected to rigorous analytical characterization, including HPLC purity analysis and structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.