Description

1,24,25,26-Tetrahydroxyergocalciferol is a highly hydroxylated derivative of ergocalciferol (vitamin D2), representing a key intermediate or active metabolite in the study of vitamin D pathways. This compound is critical for advanced research and development in pharmaceuticals and endocrinology, where precise molecular analogs are required to modulate biological activity. It is primarily utilized by research institutions and pharmaceutical companies focused on metabolic bone diseases, cancer research, and the development of novel vitamin D receptor (VDR) agonists or antagonists.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and synthetic intermediate in the development of novel vitamin D analogs for therapeutic applications.
• Biochemical Research: Used in metabolic pathway studies to understand the activation and catabolism of vitamin D2 and its physiological effects.
• Endocrinology Studies: Employed as a tool compound to investigate the Vitamin D Receptor (VDR) signaling and its role in calcium homeostasis and cell differentiation.
• Analytical Standard: Acts as a high-purity certified reference material (CRM) for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of vitamin D metabolites in biological samples.
• Nutraceutical Science: Used in advanced studies exploring the bioactivity and metabolism of vitamin D forms beyond the standard D2 and D3.

Basic Information

Product Name	1,24,25,26-Tetrahydroxyergocalciferol
CAS No.	103305-11-9
Molecular Formula	C₂₈H₄₄O₆
Molecular Weight	476.65 g/mol
Synonyms	1α,24R,25-Trihydroxyvitamin D2; 1,24,25-Trihydroxyergocalciferol; 1α,24R,25-Trihydroxyvitamin D₂; 1α,24R,25-Trihydroxyergocalciferol; Vitamin D2 metabolite 1,24,25-triol; (1α,3β,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24,25-tetrol; 1,24,25-Trihydroxyvitamin D2
EINECS	Contact for details

Quality Control

Our 1,24,25,26-Tetrahydroxyergocalciferol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.