Description

Phenserine CAS NO 101246-66-6 is a synthetic phenylcarbamate derivative and a potent, selective acetylcholinesterase (AChE) inhibitor. This compound is of significant interest in advanced pharmaceutical research for its neuroprotective properties and potential to modulate key pathways implicated in neurodegenerative conditions. It is primarily utilized by research institutions and pharmaceutical developers focused on neuroscience, cognitive disorders, and novel therapeutic discovery.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of treatments for Alzheimer's disease and other dementias.
• Neuroscience Studies: For investigating the mechanisms of cholinergic neurotransmission, synaptic plasticity, and cognitive function in preclinical models.
• Biochemical Assay Development: Used as a specific inhibitor in enzymatic assays to study acetylcholinesterase activity and screen for new AChE inhibitors.
• Mechanistic Pharmacology: Research into amyloid-beta precursor protein (APP) processing and neuroprotective signaling pathways.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Product Name	Phenserine
CAS No.	101246-66-6
Molecular Formula	C24H26N2O4
Molecular Weight	406.48 g/mol
Synonyms	(-)-Phenserine; (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl phenylcarbamate; Phenserine tartrate (salt form); Heptastigmine; AChE Inhibitor (-)-Phenserine
EINECS	Contact for details

Quality Control

Our Phenserine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity verification, and identification by spectroscopic methods (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.