Description

2'-Deoxycytidine, [2-14C] CAS NO 18923-39-2 is a carbon-14 labeled nucleoside derivative, a critical tool compound for advanced biochemical and pharmacological research. Its radiolabeled structure enables precise metabolic pathway tracing and pharmacokinetic studies, providing invaluable data for drug discovery and development. This high-purity material is essential for researchers in pharmaceutical R&D, contract research organizations (CROs), and academic institutions focusing on nucleoside metabolism, antiviral agent development, and DNA synthesis mechanisms.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of nucleoside analogs and related pharmaceuticals.
• Biochemical Pathway Analysis: Enables the elucidation of metabolic pathways involving deoxycytidine, including DNA synthesis and salvage pathways in cell culture and in vivo models.
• Antiviral and Anticancer Research: Serves as a precursor or reference standard in the development and mechanistic study of antiviral drugs (e.g., against HIV, hepatitis) and chemotherapeutic agents that target nucleotide metabolism.
• Enzyme Kinetics and Mechanism Studies: Utilized in assays to study the activity and inhibition of key enzymes such as deoxycytidine kinase, DNA polymerases, and other nucleoside-processing enzymes.
• Autoradiography and Imaging: Provides the radioactive tag necessary for autoradiographic techniques to visualize the localization of nucleosides within tissues or cellular compartments.
• Quality Control and Reference Standard: Acts as an authenticated reference material for the quality control and validation of analytical methods (e.g., HPLC, LC-MS) in pharmaceutical manufacturing and regulatory testing.

Basic Information

Product Name	2'-Deoxycytidine, [2-14C]
CAS No.	18923-39-2
Molecular Formula	C9H1314CN3O4
Molecular Weight	Contact for details
Synonyms	2'-Deoxy[2-14C]cytidine; [2-14C]-2'-Deoxycytidine; Cytosine deoxyriboside-[2-14C]; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-amino-2(1H)-pyrimidinone-[2-14C]; dCyd-[2-14C]; Deoxycytidine-2'-14C; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one-[2-14C]
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxycytidine, [2-14C] is manufactured and analyzed under strict quality systems to ensure the highest standards of radiochemical purity, chemical purity, and specific activity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with the stringent requirements of research and development. Certificates of Analysis (COA) detailing batch-specific purity, radioactivity concentration, and analytical results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep container in a secondary sealed enclosure in a dedicated, well-ventilated freezer.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solution forms)	Contact for details
Radioactivity Concentration	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.