Description

D-Glucosamine-1-14C Hydrochloride is a carbon-14 radiolabeled derivative of glucosamine hydrochloride, a fundamental amino sugar and a key precursor in the biosynthesis of glycosaminoglycans. This labeled compound is essential for conducting precise metabolic and pharmacokinetic studies, enabling researchers to trace the absorption, distribution, metabolism, and excretion (ADME) pathways of glucosamine and its derivatives. It is a critical tool for pharmaceutical R&D, biochemistry, and nutritional science laboratories focused on joint health, cartilage metabolism, and the development of novel therapeutic agents.

Application

• Pharmacokinetic and ADME Studies: Used as a radiotracer to investigate the in vivo fate, bioavailability, and tissue distribution of glucosamine in preclinical research.
• Metabolic Pathway Analysis: Enables the elucidation of biochemical pathways involved in glycosaminoglycan and proteoglycan synthesis within cartilage and connective tissues.
• Drug Development: Serves as a key intermediate in the research and development of new osteoarthritis treatments, nutraceuticals, and chondroprotective agents.
• Biochemical Research: Applied in enzymatic studies and in vitro assays to understand the mechanisms of action of glucosamine and related compounds.
• Quality Control Reference Standard: Can be utilized as an internal standard in advanced analytical methods like LC-MS for the quantification of glucosamine in complex matrices.

Basic Information

Product Name	D-Glucosamine-1-14C Hydrochloride
CAS No.	17598-71-9
Molecular Formula	C6H13Cl14CNO5
Molecular Weight	~215.6 g/mol (for unlabeled form)
Synonyms	Glucosamine-1-14C HCl; (3R,4R,5S,6R)-3-Amino-6-(hydroxymethyl)-1-14C-oxane-2,4,5-triol hydrochloride; 2-Amino-2-deoxy-1-14C-D-glucose hydrochloride; Chitosamine-1-14C hydrochloride; D-Glucosamine HCl-1-14C; 1-14C-Glucosamine hydrochloride
EINECS	Contact for details

Quality Control

Our D-Glucosamine-1-14C Hydrochloride is manufactured under controlled conditions to ensure high chemical and radiochemical purity, essential for sensitive tracer studies. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as radiochemical purity, specific activity, chemical purity (by HPLC), and identity confirmation. We adhere to stringent quality protocols suitable for research use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Radiochemical Purity	≥ 97.0%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.