Description

5-Fluoroisophthalic Acid Dimethyl Ester is a high-purity fluorinated aromatic diester, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic introduction of fluorine and reactive ester groups, enabling precise molecular modifications for enhanced performance. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors developing novel active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), leveraging fluorine's bioisosteric properties to improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers in the production of high-performance liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Incorporated as a difunctional monomer to synthesize fluorinated polyesters, polyamides, and epoxy resins, imparting improved chemical resistance, thermal stability, and low surface energy.
• Metal-Organic Framework (MOF) Precursor: Utilized as an organic linker to construct fluorinated MOFs with tailored pore sizes and enhanced selectivity for gas storage and separation applications.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex, fluorinated biaryl structures.

Basic Information

Product Name	5-Fluoroisophthalic Acid Dimethyl Ester
CAS No.	17449-48-8
Molecular Formula	C10H9FO4
Molecular Weight	212.17 g/mol
Synonyms	Dimethyl 5-Fluoroisophthalate; 5-Fluoro-1,3-benzenedicarboxylic Acid Dimethyl Ester; 5-Fluorobenzene-1,3-dicarboxylic Acid Dimethyl Ester; 1,3-Benzenedicarboxylic Acid, 5-Fluoro-, Dimethyl Ester; 5-Fluoroisophthalic Acid Methyl Ester; 5-Fluoro-1,3-phenylene Dimethyl Dicarboxylate
EINECS	Contact for details

Quality Control

Our 5-Fluoroisophthalic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.