Description

2-Bromo-3-Fluoropropionic Acid is a versatile halogenated carboxylic acid building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on a short propionic acid backbone, makes it a valuable precursor for introducing functional complexity into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated and brominated active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Peptide Mimetics & Linkers: Serves as a functionalized spacer or linker in peptide chemistry and for constructing peptidomimetic compounds.
• Material Science Monomer: Potential monomer for creating specialty polymers with unique surface properties or reactivity due to the halogen functionalities.
• Fluorine Chemistry Reagent: Acts as a source of a fluorinated alkyl segment in cross-coupling reactions and nucleophilic substitution chemistry.
• Chemical Biology Probes: Useful for labeling biomolecules or synthesizing activity-based probes for enzyme studies.

Basic Information

Product Name	2-Bromo-3-Fluoropropionic Acid
CAS No.	16652-36-1
Molecular Formula	C3H4BrFO2
Molecular Weight	170.97 g/mol
Synonyms	3-Fluoro-2-bromopropanoic Acid; 2-Bromo-3-fluoropropanoic Acid; (±)-2-Bromo-3-fluoropropionic Acid; DL-2-Bromo-3-fluoropropionic Acid; α-Bromo-β-fluoropropionic Acid; NSC 169102; Propanoic acid, 2-bromo-3-fluoro-
EINECS	240-706-9

Quality Control

Our 2-Bromo-3-Fluoropropionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. Due to its nature as a strong acid/organic solvent, it should be kept away from incompatible materials such as strong bases and oxidizing agents. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.