Description

4-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated organic building block characterized by its cinnamic acid backbone and a strategically positioned trifluoromethyl group. This compound matters for its role in modulating the physicochemical properties of target molecules, notably enhancing lipophilicity, metabolic stability, and binding affinity in advanced material and pharmaceutical research. It is primarily needed by R&D chemists and process developers in the pharmaceutical, agrochemical, and liquid crystal industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in oncology and anti-inflammatory therapies, where the CF₃ group is used to fine-tune bioactivity.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides and pesticides, leveraging its ability to improve compound penetration and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials, contributing to improved display performance and efficiency.
• Polymer Modification: Used to introduce fluorine into polymer side chains, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Building Block: A versatile reagent for cross-coupling reactions, such as Heck reactions, and for the preparation of more complex fluorinated derivatives.
• Chemical Research & Development: Essential for academic and industrial labs exploring structure-activity relationships (SAR) and the effects of fluorine substitution.

Basic Information

Product Name	4-(Trifluoromethyl)Cinnamic Acid
CAS No.	16642-92-5
Molecular Formula	C₁₀H₇F₃O₂
Molecular Weight	216.16 g/mol
Synonyms	(E)-3-[4-(Trifluoromethyl)phenyl]acrylic acid; 3-(4-Trifluoromethylphenyl)-2-propenoic acid; trans-4-(Trifluoromethyl)cinnamic acid; p-Trifluoromethylcinnamic acid; 4-(Trifluoromethyl)benzeneacrylic acid; α-Carboxy-4-(trifluoromethyl)styrene; (E)-3-(4-(Trifluoromethyl)phenyl)prop-2-enoic acid
EINECS	240-704-6

Quality Control

Our 4-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	205 - 210 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.