Description

2,2-Difluoro-3-Hydroxy-3-Methyl-Butanoic Acid is a high-value fluorinated organic acid derivative, serving as a critical building block in advanced synthetic chemistry. Its unique structure, featuring both difluoro and hydroxy functional groups, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of fluorinated polymers and specialty materials with unique surface properties and chemical resistance.
• Organic Synthesis Building Block: Utilized in multi-step synthetic routes to introduce the difluoromethyl-hydroxybutanoate moiety into more complex target molecules.

Basic Information

Product Name	2,2-Difluoro-3-Hydroxy-3-Methyl-Butanoic Acid
CAS No.	15080-23-6
Molecular Formula	C5H8F2O3
Molecular Weight	154.11 g/mol
Synonyms	2,2-Difluoro-3-hydroxy-3-methylbutyric acid; 3-Methyl-2,2-difluoro-3-hydroxybutanoic acid; α,α-Difluoro-β-hydroxy-β-methylbutyric acid; DFHMBA; 15080-23-6; Butanoic acid, 2,2-difluoro-3-hydroxy-3-methyl-
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-3-Hydroxy-3-Methyl-Butanoic Acid is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.