Description

3,4,5,6-Tetrafluoro-2-Hydroxybenzoic Acid is a highly fluorinated aromatic carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a phenolic hydroxyl group and a carboxyl group on a perfluorinated benzene ring, makes it a versatile intermediate for introducing fluorine atoms into complex molecules, thereby modifying their physical, chemical, and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise fluorination to develop new active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infective agents, where fluorination enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, as the fluorine atoms can improve lipophilicity, membrane permeability, and environmental persistence of the active compounds.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing monomers and polymers used in the production of liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) to improve thermal stability and electronic properties.
• Polymer Modification: Incorporated as a monomer or cross-linking agent to create specialty fluoropolymers with enhanced chemical resistance, low surface energy, and improved thermal stability for coatings and high-performance plastics.
• Complex Ligand Synthesis: Serves as a starting material for synthesizing fluorinated ligands used in catalysis and metal-organic frameworks (MOFs), enabling more selective and efficient chemical processes.
• Research & Development: A valuable tool in academic and industrial R&D for exploring structure-activity relationships (SAR) and developing new fluorination methodologies in medicinal and synthetic chemistry.

Basic Information

Product Name	3,4,5,6-Tetrafluoro-2-Hydroxybenzoic Acid
CAS No.	14742-36-0
Molecular Formula	C7H2F4O3
Molecular Weight	210.08 g/mol
Synonyms	2-Hydroxy-3,4,5,6-tetrafluorobenzoic Acid; 3,4,5,6-Tetrafluorosalicylic Acid; Perfluorosalicylic Acid; Tetrafluorohydroxybenzoic Acid; 2,3,4,5-Tetrafluoro-6-hydroxybenzoic Acid; TFS-OH; 14742-36-0; Benzoic acid, 2-hydroxy-3,4,5,6-tetrafluoro-
EINECS	Contact for details

Quality Control

Our 3,4,5,6-Tetrafluoro-2-Hydroxybenzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment ensures reliable batch-to-batch consistency and traceability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its acidic nature, keep away from incompatible materials such as strong bases and oxidizing agents. The container must be kept tightly sealed to protect the product from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.