Description

10,11-Dihydro-N,β-Dimethyl-5H-Dibenz[B,F]Azepine-5-Propanamine Monohydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) salt form. This compound is critical for ensuring the stability, bioavailability, and consistent efficacy of final drug formulations. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and API producers engaged in the development and production of specialized therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs).
• Neurological & Psychiatric Drug Research: Used in the development and production of compounds targeting central nervous system (CNS) disorders.
• Reference Standard: Serves as a certified reference material (CRM) for quality control, method validation, and regulatory submissions.
• Preclinical & Clinical Studies: Supplied in GMP-grade for use in toxicology studies and clinical trial material manufacturing.
• Process Chemistry: Utilized in route scouting, optimization, and scale-up activities within process R&D.
• Academic Research: Employed in university and institutional research for pharmacological and chemical studies.

Basic Information

Product Name	10,11-Dihydro-N,β-Dimethyl-5H-Dibenz[B,F]Azepine-5-Propanamine Monohydrochloride
CAS No.	10464-24-1
Molecular Formula	C20H26N2•HCl
Molecular Weight	330.90 g/mol
Synonyms	Desipramine Hydrochloride; Desmethylimipramine Hydrochloride; Norimipramine Hydrochloride; Pertofrane Hydrochloride; NSC-114901; 5-[3-(Methylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine Hydrochloride; 3-(10,11-Dihydro-5H-dibenz[b,f]azepin-5-yl)-N-methylpropan-1-amine Hydrochloride
EINECS	233-941-1

Quality Control

Our 10,11-Dihydro-N,β-Dimethyl-5H-Dibenz[B,F]Azepine-5-Propanamine Monohydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to stringent specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) or customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.