Description

Maprotiline Hydrochloride is a tricyclic antidepressant (TCA) compound, specifically a tetracyclic derivative, supplied as a high-purity active pharmaceutical ingredient (API). Its primary value lies in its potent noradrenergic reuptake inhibition, making it a critical intermediate for pharmaceutical research and development. This compound is essential for manufacturers and research institutions focused on central nervous system (CNS) therapeutics, analytical method development, and reference standard production.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the manufacture of antidepressant medications.
• Biochemical Research: Used in neuroscience and pharmacology studies to investigate noradrenergic pathways and antidepressant mechanisms of action.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for quality control and analytical testing in pharmaceutical laboratories.
• Formulation Development: Employed in pre-formulation and formulation studies for solid dosage forms like tablets and capsules.
• Metabolite Studies: Used as a parent compound in the synthesis and study of its metabolic derivatives.

Basic Information

Product Name	Maprotiline Hydrochloride
CAS No.	10347-81-6
Molecular Formula	C20H23N•HCl
Molecular Weight	313.87 g/mol
Synonyms	Maprotiline HCl; 1-(3-Methylaminopropyl)dibenzo[b,e]bicyclo[2.2.2]octadiene Hydrochloride; Ludiomil (brand name); Ciba 34,276-Ba; N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine Hydrochloride; 3-(9,10-Dihydro-9,10[1',2']-benzenoanthracen-9-yl)-N-methylpropylamine Hydrochloride
EINECS	233-746-3

Quality Control

Our Maprotiline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting stringent standards for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.