Description

Maprotiline is a tetracyclic antidepressant compound, distinct from tricyclic and SSRI classes, known for its potent noradrenergic reuptake inhibition. This active pharmaceutical ingredient (API) is critical for the formulation of effective antidepressant medications, offering a valuable therapeutic option for managing major depressive disorders. It is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antidepressant tablets and capsules.
• Neuropharmacology Research: Used as a reference standard and tool compound in studies of norepinephrine reuptake mechanisms and depression models.
• Generic Drug Production: Sourcing for the development and commercial-scale production of generic maprotiline hydrochloride medications.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and analytical method development in laboratories.
• Preclinical Studies: Utilized in animal model research to investigate efficacy, pharmacokinetics, and safety profiles.

Basic Information

Product Name	Maprotiline
CAS No.	10262-69-8
Molecular Formula	C₂₀H₂₃N
Molecular Weight	277.41 g/mol
Synonyms	Maprotiline (Base); Ludiomil (Brand Name); 1-(3-Methylaminopropyl)dibenzo[b,e]bicyclo[2.2.2]octadiene; 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)-N-methylpropan-1-amine; Ba-34,276; Ciba-34,276-Ba; N-Methyl-9,10-ethanoanthracene-9(10H)-propanamine
EINECS	233-607-1

Quality Control

Our Maprotiline is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results against relevant pharmacopeial standards (such as USP or EP) are provided to guarantee traceability and compliance for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.