Description

Imipramine Pamoate is a salt form of the classic tricyclic antidepressant (TCA) imipramine, offering enhanced stability and formulation properties. This compound is a critical active pharmaceutical ingredient (API) used in the development of controlled-release psychiatric medications. It is primarily required by pharmaceutical manufacturers and advanced research institutions for the production of antidepressant formulations targeting major depressive disorders and other related conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antidepressant medications.
• Controlled-Release Formulations: Utilized in the development of sustained-release dosage forms to improve patient compliance and therapeutic profiles.
• Neuropharmacology Research: Serves as a key reference standard and tool compound in studies of neurotransmitter reuptake inhibition and depression models.
• Generic Drug Production: Essential for companies developing and manufacturing generic versions of imipramine pamoate-based drugs.
• Analytical Standard: Used as a high-purity standard in quality control (QC) and analytical method development (e.g., HPLC, spectroscopy).
• Preclinical Studies: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies during drug development.

Basic Information

Product Name	Imipramine Pamoate
CAS No.	10075-24-8
Molecular Formula	C33H35N3O5
Molecular Weight	553.65 g/mol
Synonyms	Imipramine Pamoate Salt; Imipramine 4,4'-Methylenebis(3-hydroxy-2-naphthoate); Tofranil-PM; Imipramine Embonate; Imipramine Pamoate (USP); 5-[3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-10,11-dihydro-N,N-dimethyl-5H-dibenzo[b,f]azepine-10-propanamine compound with 4,4'-methylenebis(3-hydroxy-2-naphthoic acid); Pramin
EINECS	Contact for details

Quality Control

Our Imipramine Pamoate is manufactured under strict quality management systems. It undergoes rigorous analytical testing to meet high-purity standards suitable for pharmaceutical applications, including identification, assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results against established specifications. We can supply material compliant with relevant pharmacopeial standards (e.g., USP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.