Description

3-Trifluoromethylbutyrophenone is a versatile fluorinated aromatic ketone building block, recognized for its unique chemical reactivity imparted by the trifluoromethyl group. This compound is essential for the synthesis of complex molecules, offering enhanced lipophilicity and metabolic stability in final products. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, where the introduction of fluorine atoms is a key strategy in modern molecular design.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the creation of electron-transport materials and host compounds for efficient OLED devices.
• Advanced Material Research: Acts as a building block for polymers and coatings with specific chemical resistance and surface properties.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and creating specialized chemical libraries.

Basic Information

Product Name	3-Trifluoromethylbutyrophenone
CAS No.	1705-16-4
Molecular Formula	C11H11F3O
Molecular Weight	216.20 g/mol
Synonyms	1-(3-Trifluoromethylphenyl)-1-butanone; 3-Trifluoromethylbutyrophenone; 3'-(Trifluoromethyl)butyrophenone; Butyrophenone, 3'-trifluoromethyl-; m-Trifluoromethylbutyrophenone; 3-Trifluoromethyl propiophenone (common misnomer); 1-Butanone, 1-[3-(trifluoromethyl)phenyl]-; NSC 404087
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethylbutyrophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.