Description

Methanone, (4,6-diMethyl-5-pyriMidinyl)[4-[(3S)-4-[(1R,2R)-2-ethoxy-2,3-dihydro-5-(trifluoroMethyl)-1H-inden-1-yl]-3-Methyl-1-piperazinyl]-4-Methyl-1-piperidinyl]-, (Hydrochloride) (1:2) is a high-purity, complex organic salt with a defined stereochemistry, supplied as a dihydrochloride salt. This compound is a critical pharmaceutical intermediate or active pharmaceutical ingredient (API) building block, valued for its precise molecular architecture. It is primarily utilized by pharmaceutical R&D and contract manufacturing organizations (CMOs) engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in multi-step organic synthesis for novel drug candidates.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for potential APIs targeting central nervous system (CNS) or other therapeutic areas.
• Medicinal Chemistry Research: A valuable compound for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Preclinical and Clinical Trial Material: Supplied under controlled conditions for the production of materials required for non-clinical and clinical studies.
• Process Chemistry & Scale-Up: Employed in developing and optimizing robust, scalable synthetic routes for pharmaceutical manufacturing.
• Reference Standard: Can be used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Methanone, (4,6-diMethyl-5-pyriMidinyl)[4-[(3S)-4-[(1R,2R)-2-ethoxy-2,3-dihydro-5-(trifluoroMethyl)-1H-inden-1-yl]-3-Methyl-1-piperazinyl]-4-Methyl-1-piperidinyl]-, (Hydrochloride) (1:2)
CAS No.	869725-27-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(4,6-Dimethyl-5-pyrimidinyl){4-[(3S)-4-[(1R,2R)-2-ethoxy-2,3-dihydro-5-(trifluoromethyl)-1H-inden-1-yl]-3-methyl-1-piperazinyl]-4-methyl-1-piperidinyl}methanone dihydrochloride; (1R,2R)-1-[4-[(3S)-4-[4-(4,6-Dimethyl-5-pyrimidinylcarbonyl)-4-methyl-1-piperidinyl]-3-methyl-1-piperazinyl]-2-ethoxy-2,3-dihydro-5-(trifluoromethyl)-1H-indene dihydrochloride; UNII-8JXH22045J; 8JXH22045J; BMS-823778 (dihydrochloride); BMS 823778 dihydrochloride; BMS-823778-02; BMS823778-02
EINECS	Contact for details

Quality Control

Our Methanone, (4,6-diMethyl-5-pyriMidinyl)[4-[(3S)-4-[(1R,2R)-2-ethoxy-2,3-dihydro-5-(trifluoroMethyl)-1H-inden-1-yl]-3-Methyl-1-piperazinyl]-4-Methyl-1-piperidinyl]-, (Hydrochloride) (1:2) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) with batch-specific data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.