Description

Ly 2157299 is a potent and selective small molecule inhibitor targeting the TGF-β (Transforming Growth Factor-Beta) signaling pathway, specifically as an ALK5 (Activin receptor-like kinase 5) inhibitor. This compound is of significant interest for its role in modulating cellular processes such as fibrosis, inflammation, and tumor progression. It serves as a critical research tool for pharmaceutical R&D, particularly in the development of novel therapeutics for fibrotic diseases, oncology, and cardiovascular conditions. Researchers and development scientists in the global biotechnology and pharmaceutical sectors rely on high-purity Ly 2157299 for preclinical studies and mechanism-of-action investigations.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of anti-fibrotic and anti-cancer drugs.
• Preclinical Studies: Essential for in vitro and in vivo studies investigating the inhibition of the TGF-β/ALK5 pathway and its effects on disease models.
• Biochemical Assays: Serves as a key reagent in high-throughput screening (HTS) and enzymatic assays to identify and characterize new therapeutic candidates.
• Academic Research: Utilized in university and institutional labs for fundamental research into cell signaling, epithelial-mesenchymal transition (EMT), and tissue remodeling.
• Oncology Research: Investigated for its potential to inhibit tumor growth and metastasis by targeting the tumor microenvironment.
• Cardiovascular & Renal Research: Applied in studies focused on preventing or treating organ fibrosis, including cardiac, pulmonary, and renal fibrosis.

Basic Information

Product Name	Ly 2157299
CAS No.	700874-72-2
Molecular Formula	C₂₂H₁₉N₅O₄
Molecular Weight	417.42 g/mol
Synonyms	Galunisertib; LY-2157299; LY2157299; 4-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide; TGF-β Receptor I Kinase Inhibitor; ALK5 Inhibitor; TGF-βRI Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Ly 2157299 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality protocols are designed to support GMP-grade production requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.