Description

Triacsin B is a potent and selective inhibitor of long-chain acyl-CoA synthetase (ACSL), a key enzyme in fatty acid metabolism. This compound is a critical research tool for studying lipid biosynthesis, energy homeostasis, and related metabolic disorders. It is primarily utilized by researchers and scientists in the fields of biochemistry, pharmacology, and metabolic disease research to elucidate pathways and validate therapeutic targets.

Application

• Biochemical Research: A fundamental tool for inhibiting fatty acid uptake and triglyceride synthesis in cell-based studies.
• Metabolic Disease Investigation: Used to model and study conditions like obesity, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes.
• Pharmacology & Drug Discovery: Serves as a reference compound for screening and developing novel ACSL inhibitors for therapeutic applications.
• Cell Signaling Studies: Employed to dissect the role of lipid metabolism in cellular processes such as inflammation and apoptosis.
• Academic & Institutional Research: Essential for universities and research institutes conducting fundamental life science research.

Basic Information

Product Name	Triacsin B
CAS No.	105201-47-6
Molecular Formula	C₂₀H₂₇N₃O₂
Molecular Weight	341.45 g/mol
Synonyms	Triacsin B; 2,4,6-Heptatrienoic acid, 7-[4-[[(4-chlorophenyl)methyl]amino]-6-[(3,5-dimethyl-4-isoxazolyl)amino]-1,3,5-triazin-2-yl]amino]-7-oxo-, (2E,4E,6E)-; ACSL Inhibitor III; Long-chain acyl-CoA synthetase inhibitor; FA-CoA synthetase inhibitor; 105201-47-6
EINECS	Contact for details

Quality Control

Our Triacsin B is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and structural confirmation via mass spectrometry (MS) and NMR. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.