Description

Fidarestat is a potent and selective aldose reductase inhibitor (ARI) of significant interest in pharmaceutical research and development. Its primary value lies in its ability to modulate the polyol pathway, a key mechanism implicated in diabetic complications. This makes it a critical compound for researchers and manufacturers focused on metabolic disorders and associated neuropathy. Industries requiring high-purity advanced pharmaceutical intermediates will find this product essential for their development pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) or advanced intermediate in the synthesis of therapeutic agents targeting diabetic complications.
• Biochemical Research: Used as a reference standard and tool compound in preclinical studies to investigate the role of aldose reductase in diabetic neuropathy, retinopathy, and nephropathy.
• Mechanism of Action Studies: Employed in enzymatic assays and cellular models to study inhibition kinetics and pathway modulation for drug discovery programs.
• Formulation Development: Utilized in the development and stability testing of novel dosage forms intended for metabolic disease treatment.

Basic Information

Product Name	Fidarestat
CAS No.	105300-43-4
Molecular Formula	C₁₉H₁₇N₃O₅S
Molecular Weight	399.42 g/mol
Synonyms	(±)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-3-quinazolineacetic acid; (RS)-Fidarestat; SNK-860; FK-366; Zopolrestat analog; Aldose reductase inhibitor 860; 2-[(4-Bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-3-quinazolineacetic acid
EINECS	Contact for details

Quality Control

Our Fidarestat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development needs with material produced in facilities adhering to cGMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.