Description

n-Cbz-Pro-Leu-Gly Hydroxamate is a synthetic peptide hydroxamate derivative, specifically designed as a potent and selective inhibitor of matrix metalloproteinases (MMPs). This compound matters significantly in biochemical research and pharmaceutical development for its role in studying proteolytic enzyme activity and cellular processes. It is primarily needed by researchers and manufacturers in the fields of oncology, inflammation, and tissue remodeling, where precise enzyme inhibition is critical for therapeutic target validation and drug discovery.

Application

• Biochemical Research: Used as a standard inhibitor in enzymatic assays to study the kinetics and inhibition profiles of various MMPs, including MMP-2 and MMP-9.
• Pharmaceutical R&D: Serves as a key intermediate or reference compound in the discovery and development of novel anti-cancer and anti-inflammatory therapeutics targeting extracellular matrix degradation.
• Cell Biology Studies: Employed to investigate the role of specific MMPs in cellular invasion, angiogenesis, and metastasis in various in vitro and ex vivo models.
• Protease Inhibitor Screening: Acts as a positive control in high-throughput screening platforms to identify new classes of MMP inhibitors.
• Academic Research: Utilized in university and institutional labs for fundamental research into connective tissue diseases, wound healing, and cardiovascular disorders.

Basic Information

Product Name	n-Cbz-Pro-Leu-Gly Hydroxamate
CAS No.	103145-74-0
Molecular Formula	C₂₂H₃₂N₄O₆
Molecular Weight	448.52 g/mol
Synonyms	Z-Pro-Leu-Gly-NHOH; Carbobenzoxy-Pro-Leu-Gly Hydroxamic Acid; CBZ-Pro-Leu-Gly-NHOH; N-[(Benzyloxy)carbonyl]-L-prolyl-L-leucyl-glycine hydroxamate; MMP Inhibitor III; MMP Inhibitor Z-Pro-Leu-Gly-NHOH; CAS 103145-74-0
EINECS	Contact for details

Quality Control

Our n-Cbz-Pro-Leu-Gly Hydroxamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry and NMR, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.