Description

Epibestatin Hydrochloride CAS NO 100992-60-7 is a potent and selective inhibitor of the enzyme methionine aminopeptidase type 2 (MetAP2). This compound is of significant value in biochemical and pharmaceutical research for studying angiogenesis, cell proliferation, and tumor growth pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in oncology and metabolic disease research.

Application

• Biochemical Research: Used as a critical tool compound to investigate the role of MetAP2 in cellular processes and signal transduction pathways.
• Pharmaceutical R&D: Serves as a reference standard and a key intermediate in the discovery and development of novel anti-cancer and anti-angiogenic therapeutics.
• Cell Biology Studies: Applied in in vitro assays to study the effects of MetAP2 inhibition on endothelial cell function, tumor cell proliferation, and apoptosis.
• Preclinical Development: Utilized in animal model studies to evaluate the efficacy and pharmacokinetics of MetAP2-targeting drug candidates.

Basic Information

Product Name	Epibestatin Hydrochloride
CAS No.	100992-60-7
Molecular Formula	C₁₉H₂₀N₄O₃ • HCl
Molecular Weight	388.85 g/mol
Synonyms	Epibestatin HCl; MetAP2 Inhibitor; TNP-470 analog; Fumagillin analog; O-(Chloroacetylcarbamoyl)fumagillol Hydrochloride; AGM-1470 Hydrochloride; NSC 641530; Angiogenesis Inhibitor (MetAP2)
EINECS	Contact for details

Quality Control

Our Epibestatin Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality management standards to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.