Description

Crebinostat is a potent and selective small molecule inhibitor of histone deacetylase (HDAC) enzymes, specifically targeting Class I HDACs. This compound is a critical research tool for investigating epigenetic regulation, cellular differentiation, and disease mechanisms in oncology and neurology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and preclinical studies for cancer and neurodegenerative disorders.

Application

• Biomedical Research: A key chemical probe for studying the role of HDAC inhibition in gene expression and cell cycle regulation.
• Oncology Research: Investigated for its potential to induce differentiation, apoptosis, and cell cycle arrest in various cancer cell lines.
• Neurodegenerative Disease Models: Used in research exploring epigenetic therapies for conditions like Alzheimer's disease and Huntington's disease.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the development of novel HDAC-targeting therapeutics.
• Biochemical Assays: Employed in high-throughput screening and in vitro enzymatic assays to evaluate HDAC activity and inhibitor potency.
• Preclinical Studies: Utilized in animal models to assess the pharmacokinetics, efficacy, and safety profiles of HDAC inhibition.

Basic Information

Product Name	Crebinostat
CAS No.	1092061-61-4
Molecular Formula	C₂₁H₂₀N₄O₃
Molecular Weight	376.41 g/mol
Synonyms	Crebinostat; N-Hydroxy-4-[[(2S)-2-[[4-(1H-Pyrazol-1-yl)phenyl]sulfonyl]amino]-3-pyridinyl]methyl]benzamide; RGFP966; HDAC3 Inhibitor RGFP966; (S)-N-Hydroxy-4-((2-((4-(1H-pyrazol-1-yl)phenyl)sulfonamido)pyridin-3-yl)methyl)benzamide; UNII-2D8Q5QJ5QH
EINECS	Contact for details

Quality Control

Every batch of Crebinostat is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for pharmaceutical research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.