Description

Estatin A CAS NO 106455-06-5 is a specialized chemical compound belonging to the statin class, known for its role as a potent inhibitor of HMG-CoA reductase. This compound is of significant interest for research and development in the pharmaceutical and life sciences sectors, particularly in the study of cholesterol biosynthesis and related metabolic pathways. It serves as a critical intermediate and reference standard for scientists and manufacturers focused on cardiovascular therapeutics and biochemical research.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of cholesterol-lowering drugs.
• Biochemical Studies: Used as a potent, specific inhibitor of HMG-CoA reductase in enzymatic assays and metabolic pathway research.
• Academic & Institutional Research: Employed in universities and research institutes for studying lipid metabolism, atherosclerosis, and enzyme kinetics.
• Process Development & Scale-up: Acts as a critical building block for process chemists during the optimization and scale-up of statin-based API synthesis.
• Quality Control Laboratories: Utilized as an analytical reference standard for the identification and assay of related statin compounds.

Basic Information

Product Name	Estatin A
CAS No.	106455-06-5
Molecular Formula	C25H38O5
Molecular Weight	418.57 g/mol
Synonyms	Estatin A; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-8-Hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid; HMG-CoA Reductase Inhibitor I; Compactin-related compound; ML-236A; Antibiotic 1233A
EINECS	Contact for details

Quality Control

Our Estatin A is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.