Description

N-[2-[(2R)-5α-[3,4-Dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]tetrahydro-3β,4β-dihydroxyfuran-2α-yl]-N-[(3S,4S)-4-hydroxy-4-(5-hydroxypyridin-2-yl)-L-valyl]-L-glycyl]-L-glutamic acid is a complex, high-purity nucleoside analog derivative designed for advanced pharmaceutical research and development. This compound is critical for its potential role in targeting specific enzymatic pathways, offering a sophisticated tool for medicinal chemists. It is primarily utilized in the synthesis of novel antiviral or anticancer agents, making it essential for biotechnology and pharmaceutical companies focused on innovative therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a reference standard or probe in enzymatic studies and mechanism-of-action research.
• Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical Development: Employed in the formulation and testing of new chemical entities (NCEs) for pharmacokinetic and toxicology studies.
• Process Chemistry: Used in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	N-[2-[(2R)-5α-[3,4-Dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]tetrahydro-3β,4β-dihydroxyfuran-2α-yl]-N-[(3S,4S)-4-hydroxy-4-(5-hydroxypyridin-2-yl)-L-valyl]-L-glycyl]-L-glutamic acid
CAS No.	89156-91-2
Molecular Formula	C₂₈H₃₈N₆O₁₄
Molecular Weight	682.64 g/mol
Synonyms	L-Glutamic acid, N-[2-[(2R)-5α-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]tetrahydro-3β,4β-dihydroxy-2α-furanyl]-N-[(3S,4S)-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-L-valyl]-L-glycyl]-; Nucleoside Amino Acid Conjugate; Complex Nucleoside Derivative; 89156-91-2; (2R,3S,4S,5R)-2-((((3S,4S)-4-hydroxy-4-(5-hydroxypyridin-2-yl)-L-valyl)glycyl)amino)-5-((R)-3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl di-L-glutamate (isomeric form).
EINECS	Contact for details

Quality Control

Our N-[2-[(2R)-5α-[3,4-Dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]tetrahydro-3β,4β-dihydroxyfuran-2α-yl]-N-[(3S,4S)-4-hydroxy-4-(5-hydroxypyridin-2-yl)-L-valyl]-L-glycyl]-L-glutamic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.