Description

n-Desmethylvinblastine is a key vinca alkaloid intermediate and a significant metabolite of vinblastine, a potent chemotherapeutic agent. This compound is of critical importance in pharmaceutical research and development, particularly for the synthesis and metabolic study of anti-mitotic cancer drugs. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery, process development, and analytical method validation.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the semi-synthesis of vinblastine and related vinca alkaloid derivatives.
• Metabolite Reference Standard: Used as an analytical standard in pharmacokinetic and metabolism studies for vinblastine in preclinical and clinical research.
• Biochemical Research: Employed in studies investigating the mechanism of action of tubulin-binding agents and their impact on cell cycle arrest.
• Process Chemistry: Utilized in the development and optimization of synthetic routes for complex natural product-derived pharmaceuticals.
• Quality Control: Acts as a high-purity reference material for the identification and quantification of impurities in vinblastine active pharmaceutical ingredient (API) batches.
• Drug Discovery: Provides a structural scaffold for the design and synthesis of novel analogs with potential anti-cancer activity.

Basic Information

Product Name	n-Desmethylvinblastine
CAS No.	18172-50-4
Molecular Formula	C45H56N4O9
Molecular Weight	796.96 g/mol
Synonyms	23'-Desmethylvinblastine; Desmethylvinblastine; 23'-Demethylvinblastine; Vinblastine, 23'-desmethyl-; 3',4'-Didehydro-4'-deoxy-8'-norvincaleukoblastine; 4'-Deoxy-3',4'-didehydro-8'-norvincaleukoblastine; NSC 649572; LEV 01
EINECS	Contact for details

Quality Control

Our n-Desmethylvinblastine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, MS, NMR), and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.