Description

3',4'-Dihydroxyetoposide is a key chemical intermediate and a significant metabolite of the potent chemotherapeutic agent etoposide. This compound matters for its critical role in pharmaceutical research and development, particularly in the study of drug metabolism, mechanism of action, and the synthesis of novel anti-cancer derivatives. It is primarily needed by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery, analytical method development, and the production of high-purity reference standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method validation and quality control in drug manufacturing.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of etoposide.
• Chemical Synthesis: Serves as a sophisticated building block for the semi-synthesis of novel etoposide analogs and prodrugs with potentially improved efficacy or reduced side effects.
• Biochemical Assay Development: Employed in the development of high-throughput screening assays and enzymatic studies to understand topoisomerase II inhibition.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for fundamental cancer research and pre-clinical studies.

Basic Information

Product Name	3',4'-Dihydroxyetoposide
CAS No.	100007-54-3
Molecular Formula	C29H32O14
Molecular Weight	604.56 g/mol
Synonyms	4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]; 4'-Demethylepipodophyllotoxin β-D-glucopyranoside, 9-[4,6-O-ethylidene-]; Etoposide metabolite; 3',4'-O-Demethylenepodophyllotoxin 4-β-D-glucoside; 4'-Demethyl epipodophyllotoxin glucoside; NSC 334036; 3',4'-Didehydro-4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
EINECS	Contact for details

Quality Control

Our 3',4'-Dihydroxyetoposide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.