Description

Monomethylauristatin F CAS NO 745017-94-1 is a highly potent synthetic derivative of the natural cytotoxin dolastatin 10, functioning as a microtubule-disrupting agent. This compound is a critical payload component in the development of Antibody-Drug Conjugates (ADCs), enabling targeted cancer therapy with enhanced efficacy and reduced systemic toxicity. It is essential for pharmaceutical R&D teams, biotech companies, and contract research organizations (CROs) focused on next-generation oncology therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Payload: Primary use as the cytotoxic warhead conjugated to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: A key tool compound for in vitro and in vivo studies investigating mechanisms of tubulin inhibition and apoptosis.
• Preclinical Drug Development: Used in the synthesis and optimization of novel linker-payload constructs for ADC platforms.
• Bioconjugation Studies: Serves as a model payload for developing and validating new conjugation chemistries and technologies.
• Potency Reference Standard: Employed as an analytical standard in quality control and assay development for ADC manufacturing.

Basic Information

Product Name	Monomethylauristatin F
CAS No.	745017-94-1
Molecular Formula	C39H67N5O7
Molecular Weight	718.0 g/mol
Synonyms	MMAF; Dolastatin 10 Derivative; (2S)-2-[(2S,3R)-3-[(2S)-2-[(2R,3R)-3-[(2S)-2-[(2R)-2-[(2S,3S)-3-[(2S)-2-(2,5-dioxopyrrolidin-1-yl)propanamido]-2-methylbutanamido]-3-phenylpropanamido]-3-methylbutanamido]-3-methoxy-2-methylpropanamido]-3-(4-hydroxyphenyl)propanamido]-N,3-dimethylbutanamide; Auristatin F MMAF; mc-MMAF
EINECS	Contact for details

Quality Control

Our Monomethylauristatin F is manufactured under strict quality systems to ensure the high purity and consistency required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and can provide material suitable for preclinical and clinical-stage applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.