Description

10-Deacetylbaccatin Iii is a key diterpenoid intermediate and a vital precursor in the semi-synthesis of potent anticancer agents. Its value lies in its role as a biosynthetic building block for taxane derivatives, which are critical in advanced pharmaceutical research and development. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors focusing on oncology drug discovery and production.

Application

• Pharmaceutical Intermediate: Primary use as a crucial starting material for the semi-synthetic production of paclitaxel (Taxol®) and docetaxel.
• Oncology Research: Serves as a reference standard and biochemical tool in cancer research, particularly for studying microtubule stabilization mechanisms.
• Biosynthetic Studies: Used in metabolic pathway analysis and the study of taxane biosynthesis in plants like the Pacific Yew (*Taxus brevifolia*).
• Fine Chemical Synthesis: A versatile scaffold for the synthetic modification and development of novel taxane analogs with potential therapeutic properties.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	10-Deacetylbaccatin Iii
CAS No.	32981-86-5
Molecular Formula	C29H36O10
Molecular Weight	544.59 g/mol
Synonyms	10-Deacetylbaccatin III; 10-DAB III; NSC 654239; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-4,6,9,11,12a-pentahydroxy-4a,8,13,13-tetramethyl-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-2-one; 10-Deacetylbaccatin
EINECS	Contact for details

Quality Control

Our 10-Deacetylbaccatin Iii is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.