Description

10-Hydroxycamptothecin is a potent, naturally derived alkaloid and a key intermediate in the synthesis of various topoisomerase I inhibitor drugs. This compound is valued for its critical role in pharmaceutical research and development, particularly in the creation of novel anticancer therapeutics. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors engaged in oncology drug discovery and production.

Application

• Pharmaceutical Intermediate: Primary use as a crucial building block for synthesizing potent anticancer agents like irinotecan and topotecan.
• Oncology Research: Used as a reference standard and active compound in biochemical and cellular assays to study topoisomerase I inhibition and apoptosis.
• Drug Discovery & Development: Serves as a lead compound for the design, synthesis, and screening of new chemotherapeutic candidates.
• Biochemical Studies: Employed in mechanistic studies to understand DNA damage and repair pathways in cancer cells.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for preclinical cancer research.
• Fine Chemical Synthesis: Acts as a starting material for the preparation of more complex camptothecin analogs with modified pharmacological properties.

Basic Information

Product Name	10-Hydroxycamptothecin
CAS No.	19685-09-7
Molecular Formula	C20H16N2O5
Molecular Weight	364.35 g/mol
Synonyms	10-HCPT; (S)-10-Hydroxycamptothecin; 10-Hydroxy-20(S)-camptothecin; NSC 107124; Camptothecin, 10-hydroxy-; (19S)-10-Hydroxycamptothecin; 10-Hydroxy-(S)-camptothecin; Lurtotecan intermediate
EINECS	Contact for details

Quality Control

Our 10-Hydroxycamptothecin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.